Centre for Advanced Studies, IIT Bombay,
in collaboration with the
Quantitative Life Sciences Section of ICTP,
Italy,
is organizing a monthly colloquium series to be held on the 2nd
Wednesday of every month.
The inaugural colloquium will be delivered by
Prof. Édgar Roldán, ICTP.
Title: Stochastic thermodynamics of active fluctuations in the
ear of the bullfrog
Date: 9th March 2022 (Wednesday)
Time: 3:30PM IST / 11AM CET
Abstract: Stochastic thermodynamics is an emerging field that
studies the thermodynamics of systems driven out of equilibrium in
the presence of fluctuations. Unprecedented joint theoretical and
experimental advances have revealed novel universal thermodynamic
laws at the mesoscale, which includes fundamental constraints for
biological processes. This colloquium will showcase recent
progress on the application of stochastic thermodynamics to
analyze fluctuations of hair-cell bundles responsible of sound
transduction in the bullfrog's sacculus. Through a holistic
theory-experiment approach, it has been shown that spontaneous
hair-cell bundle fluctuations are nonequilibrium, i.e. active.
Moreover, using time-irreversibility measures and thermodynamic
uncertainty relations we have estimated the rate of entropy
production of hair-bundle fluctuations in different experimental,
physiological conditions [1]. Furthermore, we have introduced and
solved analytically a non-Markovian model that we have employed
successfully in parametric inference and to predict the minimal
energetic cost required to sustain spontaneous otoacoustic
emissions in the ear of the bullfrog [2].
[1] É Roldán et al., New Journal of Physics 23, 083013 (2021)
[2] G Tucci et al., arXiv:2201.12171 (2022)
We cordially invite you all to attend the colloquium. Please
forward to other colleagues and students who may be interested.
Best regards,